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One of AFWERXs first innovations with the program was its Open Topic approach, which allows companies with an innovative solution to pitch it without matching it to an already articulated military problem (the program has traditionally selected these research topics, sometimes with great specificity that risked inadvertently being too prescriptive in how a problem is to be solved in the solicitations)

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The off-the-shelf, universal engineered cell approach is ahead of the inverse vaccines so far, and the refinements in the works are extensive, as shown in the Figure below