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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209
For example, 4-HNE can induce the activation of transcription factor such as nuclear factor kappa light chain enhancer of activated B cell (NF-B) and hypoxia induced factor-1 alpha (HIF-) to mediate pro-survival and angiogenic signals [58, 59]
If you observe these symptoms, inform your doctor immediately
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What's more, animal research finds that allulose may suppress fat absorption in the small intestine so that it is excreted instead
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