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In human studies conducted to date, no increased risk of thyroid cancer has been established, but the warning remains in place given the rodent data and the fact that long-term human data is still accumulating
This may also be referred as GIP resistance: a significantly reduced ability of GIP to stimulate insulin secretion even in hyperglycemia
*Disclaimer: Major Players sorted in no particular order Recent Industry Developments March 2023: Novo Nordisk announced headline results from the PIONEER PLUS trial, a phase 3b, 68-week efficacy and safety trial with once-daily oral semaglutide 25 mg and 50 mg versus 14 mg as an add-on to a stable dose of 1-3 oral antidiabetic medicines in people with type 2 diabetes in need of treatment intensification
Pendulum will need to produce stronger clinical evidence to maintain relevance as orally available pharmaceutical alternatives emerge
Always consult with a healthcare professional before starting any medication, including GLP-1s