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the reduced dye then undergoes non-enzymic oxidation in air, so the addition of a relatively small amount of methylene blue will effectively deplete NADPH, and would be expected to stimulate any pathway that reduces NADP+ to NADPH

This does not necessarily mean you should stop after 18 months, but it does mean that long-term users should be more vigilant about monitoring and prevention strategies

Some studies have examined formal cognitive testing, with mixed results

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However, maintaining a healthy lifestyle and a well-planned diet can help you prevent weight regain