Weight loss may be slow: While some patients lose a few pounds of water weight or inflammation in the first few weeks, significant, rapid fat loss usually does not occur until you step up to higher therapeutic doses (such as 0.5 mg, 1.0 mg, or higher, depending on your doctors plan)
The most commonly observed side effects in the trial were nausea, diarrhea, and vomiting
Importantly, their study also found increased risk of gastrointestinal disorders, 5557 hypotension and syncope (some prior evidence of blood pressure-lowering 5860 ), arthritic disorders, nephrolithiasis (alternative medications may be relatively more protective 61,62 ), interstitial nephritis, and drug-induced pancreatitis (adverse events have been reported 63,64 ) associated with GLP-1 RA use
Invokana Prescribing Information
Brazeau, P
The catch is, all these trials use different doses (from 300 to 1,500 milligrams per day) and duration (1 to 24 months), so its tough to know exactly what happens when you take berberine
