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None of this constitutes a pharmacological drug interaction in the classical sense

In vivo assessments in mice with cecal ligation and puncture (CLP)-induced ALI have consistently revealed anti-inflammatory outcomes, such as reduced macrophage aggregation, downregulated pro-inflammatory cytokines, and alleviated pulmonary edema and vascular leakage, which are associated with improved survival rates [238]

Data Availability Statement Data sharing is not applicable as no new data were generated.

Orforglipron was originally discovered by Chugai Pharmaceutical and licensed by Lilly in 2018

doi: 10.3389/fnins.2024.1383355 99