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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

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PubChem Compound Summaries for BPC-157 (CAS 137525-51-0), Thymosin 4 / TB-500 (CAS 77591-33-4), and GHK-Cu (CAS 89030-95-5): sequences, molecular formulae, and molecular weights

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Retrieved 14 February 2026