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Doi:10.1056/NEJMoa1603827 This content is provided for informational and educational purposes only

The FDA requires a black box warning about seizure risk (higher with high-fat meals, alcohol, or abrupt alcohol withdrawal) and about neuropsychiatric effects from bupropion including changes in mood, behavior, or suicidal thoughts

However, while these drugs have a place in the fight against obesity, metabolic (bariatric) surgery remains the most effective, long-term solution for severe obesity and metabolic diseases

Mild side effects such as nausea, digestive changes, or fatigue may occur, but they typically improve as the body adjusts

A: Orforglipron is a once-daily oral GLP-1 receptor agonist, while Ozempic is a once-weekly injectable semaglutide medication

Who should avoid Contrave