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KFFs analysis of newly released Medicare Part D spending data from CMS shows that total gross Medicare spending on the three newest versions of these diabetes medications that have also been recently approved for weight loss Ozempic, Rybelsus, and Mounjaro has skyrocketed in recent years, rising from $57 million in 2018 to $5.7 billion in 2022 (Figure 1)

Investors including Bain Capital backed the company's thesis that next-generation multi-receptor agonists and oral small molecules could capture meaningful share from first-generation agents

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A new double agonist, tirzepatide, marketed as Mounjaro, mimics two, theoretically doubling the strength of the weight-loss effect

Derivatives and Combination : Compound that is structural variation of the main compound

Despite the lack of conclusive long-term data, the management of weight should be a priority in obese patients with hypertension, given the promising results from recent studies