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These peptides penetrate into the lining of the small intestine, where they are modified by the enzyme tissue transglutaminase 2

Supplies Needed Quantities below assume a 16week once-weekly course with gradual titration

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Local GI effects (gastric mucosal protection, intestinal barrier restoration) are well-documented in IBD and ulcer models

Combined treatment with IGF-IR inhibitor, PARP inhibitor, and/or platinum may be a strategy to improve the efficacy of cancer therapy [100]

The trade-off is that lower concentrations deplete the vial faster across multiple doses