tirzepatide action Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review Putative mechanism(s) of action of

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PMCID: PMC7588079

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The Bottom Line: Building Long-Term Success on GLP-1 Medications GLP-1 medications can support meaningful weight loss and metabolic improvements, but long-term success depends on sustainable nutrition, regular physical activity, muscle preservation, and healthy daily habits

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The further synergistic combination approach with other gastrointestinal hormones and creation of dual GIP/GLP-1 receptor agonists, such as tirzepatide and GLP-1/GIP/glucagon receptor triagonist, retatrutide, has shown unprecedented pharmacologically achieved weight loss with further cardiometabolic benefits in both obesity and T2DM