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Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: A gene expression study in hypopituitary men

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Notably, SURPASS-2 compared tirzepatide directly against semaglutide 1 mg, a well-established GLP-1 receptor agonist

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Its primary route of elimination is metabolism following proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid side chain, with excretion via urine and feces and roughly 3% of the dose excreted in urine as intact semaglutide