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The distinction carries several practical consequences that the literature illustrates: One important corollary: because MK-677 depends on a functioning pituitary, its effect is fundamentally capped by the somatotrophs capacity to respond
Zou et al., 2020)
Following injection, AdV particles target innate immune cells like DCs and macrophages and stimulate innate immune responses by engaging multiple pattern-recognition receptors including those that bind dsDNA in particular TLR9 to induce type I interferon secretion 8
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doi:10.1159/000516050
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