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Duration of trials and organisms employed has varied, but there have been several instances of positive results (Rogler 2011)

Advantages: - Once-weekly convenience for most formulas - Well-studied efficacy and safety data - More consistent absorption - Compounded versions available at lower cost Considerations: - Requires self-injection or provider administration - Needles can be a barrier for some patients Oral semaglutide (Rybelsus) is currently the only FDA-approved oral GLP-1 medication

P = 0.0162) and severe nonproliferative DR (OR, 0.72

Pregnancy/Breastfeeding: Not recommended

So loss in skeletal muscle (when it occurs) is more an indirect effect