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They observed that COMBI therapy was superior to LIRA and MET monotherapy in reducing weight, BMI, and WC in women with PCOS previously poor responders to weight loss on metformin monotherapy

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Because it engages an additional glucagon pathway beyond dual-agonist compounds, retatrutide is frequently studied alongside Semaglutide (a mono-agonist) and Tirzepatide (a dual-agonist) to compare multi-receptor pharmacology

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The fat-metabolism-focused small peptide alternative to full GH-axis engagement