Many protocols explore twice-weekly subcutaneous or intramuscular administration during a loading phase, transitioning to reduced frequency
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The most significant published data comes from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al
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While there is a growing body of preclinical research suggesting metabolic benefits, robust human clinical trials particularly large-scale, randomised controlled trials (RCTs) are largely absent