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[1] If you experience persistent or concerning symptoms after starting B12 supplements, particularly skin changes or gastrointestinal issues, it is advisable to discuss these with your GP rather than assuming they are directly caused by vitamin excess

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Its most consistently documented mechanism involves VEGFR2 activation and Akt-eNOS signaling, promoting angiogenesis in connective tissue research models (Hsieh et al., Journal of Molecular Medicine, 2017, DOI: 10.1007/s00109-016-1488-y)

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Yet, when standardized for body weight variations, the BMC to body weight ratio appeared consistent