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The primary objective of the phase 3b SOUL trial was to evaluate the effects of oral semaglutide 14 mg, in addition to standard of care, on reducing the risk of MACE in adults with type 2 diabetes at high risk for major cardiovascular events

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Lower doses show reduced effectiveness

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The authors of the current study wanted to examine more of the potential psychiatric effects of GLP-1RAs, particularly how they relate to depression