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The GLP-1R is expressed on - (glucagon secreting), - (insulin secreting), and - (somatostatin secreting) cells of pancreatic islets, as well as in the heart, lung, kidney, stomach, small intestine, skin, and nerves in the peripheral and central nervous systems (PNS and CNS)

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Reporting Adverse Events If you experience concerning side effects, seek immediate medical care

This adjustment phase is usually temporary as the body finds a new set point for its metabolism, but it can be disruptive in the early weeks of treatment