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These results suggest that activation of sphingosine-1-phosphate receptor 2 inhibits remyelination and exacerbates BBB permeability and demyelination

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Once the AMPK signalling pathway is activated, it regulates key enzymes in several metabolic pathways, including lipid and glucose metabolism, mitochondrial dynamics, autophagy, and protein synthesis through phosphorylation, thereby helping to restore mitochondrial energy homeostasis [96, 97], which, when disrupted, damages mitochondria

When insulin/GLP-1RA fixed-ratio combinations are compared with basal insulin, a superiority in reducing HbA1c is observed, with overall benefit also in weight neutrality or weight loss, reduced hypoglycemia risk, and reduced insulin-dose requirement [19, 25,26,27, 30, 31]

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