Retatrutide is not simply a more potent weight-loss agent
After opening the product in solution form (spray), it is recommended to store it in a cool place, preferably in the refrigerator, to maintain the full stability and activity of the active substance for as long as possible
STEP trials showed approximately 40% of weight loss was lean mass
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Conducted as a prospective cohort study, it included 35 participants with a BMI ranging from 30 to 40 kg/m, who participated in an eight-week weight loss program with daily administration of 15 mg of phentermine [35]
However, it remains unclear whether this would be feasible in individuals with diabetes, as diabetes itself has been associated with impaired GLP-1 responses to nutrient ingestion (4-7), albeit inconsistently (8, 9), in part due to the use of different assays