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These effects typically resolve as the body adapts to the medication

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Potential side effects include abdominal discomfort, constipation, diarrhea, nausea, vomiting, fatigue, headache

AST and ALT elevations indicate hepatic stress

Separate signaling cascades can also determine an increase of cytosolic Ca 2+ which includes the phosphorylation of PKA after GLP-1 receptor activation, the increase of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) levels and the mobilization of Ca 2+ stores [33, 36]

The phase 2 trial tested different starting dose strategies and found that slower titration reduced side effects but also delayed the onset of maximum weight loss