The DPP4-resistant GLP-1R agonist, liraglutide, is now in clinical use as a weight-loss therapeutic in obese/overweight individuals (97)
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These findings provide clinical evidence that prostate differentiation and growth as well as circulating PSA level is mediated largely by DHT
He also said more research to understand the potential risks in healthy individuals such as athletes "would be worthwhile.'' USADA, the national anti-doping organization, has seen no evidence of rampant use of GLP-1s by athletes, according to Fedoruk
Despite reduced appetite, patients should aim to consume regular, balanced meals containing: Adequate protein (lean meats, fish, eggs, legumes, dairy) to support muscle mass and energy metabolism Complex carbohydrates (whole grains, vegetables, fruits) for sustained energy release Healthy fats (nuts, seeds, olive oil, avocado) for satiety and nutrient absorption Micronutrients from a varied diet, particularly foods containing B vitamins, iron, and vitamin D, which are essential for energy production Small, frequent meals may be better tolerated than large portions, helping to manage nausea whilst ensuring sufficient caloric intake
Combined with slowed emptying, this can worsen acid reflux, heartburn, and nausea that many people already experience on GLP-1 medications
