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Our data suggest exendin-P5 may induce a looser coupling between the ligand TMD and G s binding sites, potentially linked to the more short-lived interactions with TMD residues, resulting in higher efficacy due to faster G s conformational transitions associated with nucleotide exchange and faster G s dissociation

doi: 10.1186/s12917-015-0394-9 35 FlemingS

Furthermore, ongoing studies are exploring its potential cardiovascular and kidney benefits

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Schroeder, G

However, results across studies vary, and larger trials are necessary to confirm these preliminary findings