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The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain

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A head-to-head comparison revealed that both semaglutide and tirzepatide reduced the composite risk of hospitalization for HF or all-cause mortality by over 40% relative to placebo, with no significant advantage of tirzepatide over semaglutide

5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame