Other laboratory abnormalities include macrocytic anaemia due to folate (or, rarely, vitamin B 12 ) deficiency, coagulopathy resulting from vitamin K deficiency, or vitamin D deficiency leading to hypocalcaemia and an elevated alkaline phosphatase level.[8] Other increasingly recognised extra intestinal manifestations include bone fractures,[9] infertility,[10] psychiatric syndromes,[11] and various neurologic conditions, including peripheral neuropathy, ataxia, and seizures.[12] Autoimmune diseases occur more commonly in patients with coeliac sprue, especially type 1 diabetes mellitus[13] and autoimmune thyroiditis.[14] The prevalence of coeliac sprue in patients with type 1 diabetes is approximately 3 to 8 percent.[15] Comment The incidence of CD is increasing across all age ranges and yet remains grossly underdiagnosed
It forms a fibrous network in the skin, along with providing the mechanical structural components of the extracellular matrix of the dermis [10, 26]
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Peptide bonds remain stable because there's insufficient kinetic energy or water activity to drive hydrolysis
Varga, Flammer (85) found direct viral infection of the endothelial cells and diffuse endothelial inflammation, with endothelial and inflammatory cell death in an autopsy of patients with COVID-19
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