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The haem released by the hydrolytic digestion of haemoglobin is catabolized by haem oxygenase to generate active iron and forms iron-ferritin deposition

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Nonetheless, different animal models deficient for GLP-1 signaling, in addition to human studies, prove the dispensability of GLP-1 for surgical success (3134), questioning the causative nature of GLP-1 for the reported metabolic benefits