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While there are still gaps in our knowledge, there are many potential avenues of future studies to elucidate the complex mechanisms by which IGF-1 interacts with environmental variables to enhance bone elongation

To control for population stratification, we only included participants with white British ancestry in the analysis

Whilst many symptoms improve with appropriate B12 treatment, not all resolve completely, especially if neurological damage was severe or prolonged before treatment commenced

3) For large volume of supernatant, concentrate the proteins by ammonium sulphate precipitation, dialyze the dissolved protein solution against 1 PBS, and then apply the solution onto the GSH column