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Specifically, a dose of 200 mg/kg SAE demonstrated the most significant benefits, characterized by a marked reduction in reactive oxygen species (ROS) production, an enhancement of antioxidant defenses within the lens, a decrease in lipid peroxidation, a suppression of apoptotic processes, and an increase in cell proliferation

Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1

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This often leads to fatigue and dizziness among patients, making it challenging to stay active and continue treatment

We further describe how inflammatory and metabolic signals interact to amplify ferroptosis, creating a self-reinforcing cycle of tissue damage