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GLP-1 drugs target brain neurons that control appetite but frequently cause side effects

Reports of severe adverse events include allergic reactions ranging from mild rashes to anaphylactic shock, kidney dysfunction particularly with high doses or prolonged use, liver toxicity in susceptible individuals, and thyroid dysfunction affecting hormone regulation

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Efficacy of various hypoglycemic agents in the treatment of patients with nonalcoholic liver disease with or without diabetes A network meta-analysis