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that bone loss was most pronounced in weight-bearing skeletal sites, with no significant changes in non-weight-bearing areas such as the radius, suggests that mechanical unloading may be a key driver of bone resorption rather than a direct pharmacologic effect of GLP-1 receptor activation
That is the accurate description, and it is much weaker than clinically studied. There is also a mechanistic argument buried in Ionescu & Frohman that deserves attention: 90 mcg/kg produced no significant additional response over 60 mcg/kg [5]
Jan 5, 2026 Bone, despite being highly vascularized tissue, requires precise orchestration of inflammatory phase (hematoma formation, cytokine release), repair phase (callus formation, cartilaginous bridge), and remodeling phase (ossification, mechanical adaptation) spanning weeks to months
Finally, there's the angle of Nutrient Replenishment
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