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Journal of experimental & clinical cancer research: CR

STZ, streptozotocin

When more free radicals exist than antioxidants, oxidative cell damage occurs

Moreover, the use of drugs affecting mitochondria, where more than one-half of all ROS are generated, represents a suitable approach to induce oxidative stress and PCD in cancer cells 109 : gamitrinib, an inhibitor of heat shock protein 90 (HSP90), induces a dramatic collapse of mitochondria in prostate cancer cells 110 , while ARQ 501 (a quinone derivative) and STA-4783 (a copper chelator) increase ROS through leakage in the electron transport chain and have beneficial effects in patients with solid tumors and pancreatic adenocarcinoma 111

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Funding The author(s) declare that financial support was received for the research and/or publication of this article