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Earlier studies demonstrated that monozygotic twins have significantly greater concordance for ASD than dizygotic twins, and ASD heritability is estimated to be 83% [7]

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PMID: 3776352

Reading these together, the case for the pairing is mechanistic and evidentiary rather than direct

The most frequent causes include liver disease (which releases stored B12), vitamin B12 supplementation, renal impairment reducing clearance, and non-malignant haematological disorders

In fact, a strong argument can be made that B12/MIC is a particularly versatile inhibitor of mTOR precisely because its various components each work to combat distinct catalysts of mTOR stimulation