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In a TODAY segment that aired on Nov

Semaglutide can help people lose an average of 18% of their body weight at the highest dose (Wegovy 7.2 mg), and tirzepatide has been associated with an average of 21% at the 15 mg dose of Zepbound

While Novo Nordisk and Lilly seem best positioned now, emerging agents, oral options, dual/triple agonist molecules may capture niches or even displace certain uses of the first wave of GLP-1s

The practical goal is to reduce avoidable contributors: titrate thoughtfully rather than racing to the highest dose, avoid unnecessarily rapid weight loss, prioritize adequate protein, perform resistance training to preserve lean tissue, and monitor for iron, zinc, vitamin D, vitamin B12, vitamin A, and other deficiencies when intake is substantially reduced

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Experiencing increased cramping or changes in PMS (premenstrual syndrome) symptoms may also coincide with the use of semaglutide