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R.HochbergM.WhiteD.RodeoS.HuardJ.ShapiroS.et al (2025)

It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

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