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This class of medication represents the third-highest selling class of drugs in the United States, with $13.9 billion in annual sales.[127] Sales of Nexium (the purple pill by Astra Zeneca) topped $6.1 billion in 2013 alone, the second highest prescribed medication in the U.S.[128] In this article we take a closer look at the known risks associated with the use of PPIs, according to the most recent literature

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