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In a single piece, he concisely captures: the state of the field the most important clinical trials where the pipeline is headed These Clinical trials are raising the bar and expanding future treatment options: Retatrutide ~24% weight loss (triple agonist) MariTide 1216% weight loss (GLP-1 + GIP antagonist) CagriSema up to 20% weight loss + ~2% HbA1c drop Orforglipron oral GLP-1, HbA1c 1.5%, weight 7.6% IcoSema weekly semaglutide + once-weekly insulin Even more exciting
Small-Molecule GLP-1 Drugs Target the Brains Emotion and Reward Centers Peptide GLP-1 agonists are difficult to manufacture, store, and administerthey must be injected
Many users find it helpful to build a morning routine around this windowlike journaling, light stretching, or getting ready for the dayso the delay feels purposeful rather than restrictive
Some studies report risks of pancreatitis and gallbladder complications with prolonged use
Sakaeda T, Tamon A, Kadoyama K, Okuno Y
doi: 10.1056/NEJMoa1612917 19 LeiterLACarrMCStewartMJones-LeoneAScottRYangFet al
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