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After years of research in the 1970s90s, GLP-1 studies and clinical trials were conducted throughout the early 2000s

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The researchers examined weight regain, waist circumference, blood sugar levels, blood pressure, and blood lipid levels: A phenomenon known as metabolic rebound. The weight comes back and sometimes sooner than expected Among people treated for obesity, an average increase of about 5.6 kg was recorded after stopping treatment

However, in time, it was discovered that the drug could aid weight loss by curbing appetite

- Depending on your meal frequency, this can be up to three times a day

It was described as semaglutide matching placebo (Ref 6)