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Table 2 Small molecular metabolite targets and their agents in rheumatoid arthritis

This is a space for thoughtful explorers and evidence-minded pioneers

Prescribers initiating BPC-157 in patients with Child-Pugh A or B hepatic impairment should document: (1) the clinical rationale for peptide therapy, (2) the absence of an FDA-approved alternative for the target condition, (3) baseline hepatic function with planned monitoring intervals, and (4) the patient's informed consent acknowledging the investigational nature of the therapy and the specific evidence limitations in their population

National Institutes of Health (NIH) PMC

Kundu R, Narean JS, Wang L, Fenn J, Pillay T, Fernandez ND, et al

HIF-1 is a transcription factor that controls the expression of genes related to inflammation, angiogenesis, and energy metabolism 25,26