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The experiments were conducted by placing the mice in one of four 50 50 50 cm arenas immediately after compound administration, allowing their locomotion to be monitored by a ceiling-mounted Logitech C920 Pro camera (1,080 1,080 px, 30 fps, Logitech software)

A novel isoliquiritigenin loaded self-nanoemulsifying drug delivery system was developed for isoliquiritigenin and demonstrated improved bioavailability in vivo 3.92 , mainly attributed to the poor absorption, low intestinal permeability and rapid elimination of free isoliquiritigenin [116]

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Figure: DISULFIDE - CYSTINE - REACTIONS When a protein folds, two Cys side chains might approach each other, and form an intrachain disulfide bond