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The SURMOUNT clinical trials demonstrated that tirzepatide's 4-week dose-escalation protocol led to substantial weight loss of 20% to 22% of baseline body weight over 68 weeks

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Simultaneously, the level of local transferrin decreased after treatment with iron-chelating agent deferoxamine (DFO)

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Since 2006, glucagon-like peptide-1 receptor (GLP-1R) agonists have caused a dramatic change in the treatment of type 2 diabetes, with clinically relevant and sustained effects on glycaemic control and body weight combined with cardioprotective mechanisms [3, 4]