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Maintenance of weight loss: once therapeutic levels have helped patients achieve their goal weight, lowering the dose may be a helpful longer-term way of keeping them there

Box 1 Homosynaptic and Heterosynaptic Plasticity

The GLP-1 agonists market therefore continues to tilt toward long-acting injectables, anchoring semaglutide and tirzepatide at the forefront while relegating older daily products to niche status

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Dose adjustments or timing changes can improve tolerance while you continue therapy

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