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UCDavis Health (2023) Efficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10), Diabetes & Metabolism (2019) Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials, The Lancet (2019) Management of Hyperglycemia in Type 2 Diabetes, 2018

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More than four in ten Americans (43%) cite issues such as Ozempic face, hollowed features, or sagging skin as a reason they would not take a GLP-1, even if recommended by their doctor

Pfizer said it tested four formulations of the drug to determine which might be most effective, but didnt disclose which worked best, just saying one showed the most favorable profile. Candidly, todays trial never answered the question on what once-daily modified release dose would get to competitive efficacy, Raffat said in a note to investors

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