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Mutations in AR receptor, AR overexpression, intracrine production, contorted expression of enzymes and cofactors of AR, autonomous activation of AR signaling by cytokines in the absence of androgen ligands, and the presence of multiple splice variants of AR are the main causative agents responsible for the therapeutic failure [12, 13]
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Because Tesamorelin and Ipamorelin activate different receptors, they are often combined in non-label research protocols to produce larger summed GH pulses than either alone
Convenience : Weekly GLP-1 injections (like Ozempic) have better adherence than daily options (like Saxenda)
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