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All systems in human body suffer from compromized mitochondrial health but the most affected are highly energy-consuming ones which are the heart, the central and peripheral nervous system, and skeletal and smooth muscles resulting in frequently fatal cardiac deficits (heart failure, sudden heart arrest), accelerated brain aging/neurodegeneration, and a spectrum of muscular pathologies

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Moreover, clinical trials in patients with diabetes are affected by many complex factors, such as diet, race, comorbidities, and drug combinations

Antonucci S, Di Lisa F, Kaludercic N

Randomized controlled trial of compressive cryotherapy versus standard cryotherapy after total knee arthroplasty: pain, swelling, range of motion and functional recovery