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The evidence base is overwhelmingly preclinical, and there are no completed, published Phase 2 or 3 human efficacy trials only early-stage safety work [9]

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The pelvic floor muscles may be a cause of the symptoms, or may be a secondary finding due to prolonged symptoms and can play a role in maintaining these symptoms

Valproate competes with phenytoin for binding to albumin, which increases the free level of phenytoin