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For gut healing specifically, taking it orally or intraperitoneally puts the peptide in direct contact with the gut lining

Tacelli M, Celsa C, Magro B, et al

65 Immune-Inflammatory Mechanisms: Systemic Low-Grade Inflammation and Mucosal Damage The gastrointestinal tract is not only the site of digestion and absorption but also the bodys largest immune organ, involved in immune responses and inflammatory processes

You can read the full article at A phase 1 multiple-ascending dose study of tirzepatide in Japanese participants with type 2 diabetes This study aimed to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of tirzepatide in Japanese individuals with type 2 diabetes (T2D)