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A possible explanation for this observation is that ribose-5-phosphate in G6PDH-null chondrocytes is generated by reversal of the non-oxidative arm of the PPP (non-oxPPP), which results in the conversion of glycolytic intermediates (fructose-6-P and glyceraldehyde-3-P) into ribose-5-phosphate by transketolase and transaldolase (Fig

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Consequently, the activation of RAS transcription triggers the downstream activation of two distinct yet interconnected pathways such as the PI3K-AKT signaling pathway and the RAFMEKERK pathway