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Hamid PH, Prastowo J, Ghiffari A, Taubert A, Hermosilla C

Bull Exp Biol Med 146(5):624626

NRF2 enhances the expression of genes involved in glutathione biosynthesis and the detoxification of lipid peroxidation products [10]

He neither recommended it nor advised against it

With advancing age, mitochondrial function deteriorates, characterized by increased ROS production, accumulation of mitochondrial DNA (mtDNA) mutations, altered mitochondrial dynamics, a decline in the mitochondrial unfolded protein response (UPRmt), and reduced respiratory chain activity (Sun et al., 2023) Additionally, AS-IV reduces ROS overproduction and mitochondrial dysfunction induced by angiotensin II (Ang II), thereby inhibiting vascular smooth muscle cell senescence (Lu Y