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doi: 10.1038/s41467-021-23014-1 264 FriedLPTangenCMWalstonJNewmanABHirschCGottdienerJet al

Nausea is by far the most frequently reported adverse effect across every GLP-1 receptor agonist studied

Muscle is metabolically active tissue: it is where most of your glucose gets used, so holding onto it supports the blood-sugar benefits many people are on these medications for in the first place

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Homozygous NKO mice exhibit embryonic lethality [68], whereas heterozygous NKO mice exhibit IGT due to impaired insulin secretion [68] and heart failure due to progressive mitochondrial dysfunction induced by pressure overload [69]